Your body already makes the best anti-inflammatory.
This turns it back on.

No, and we'd be lying if we said it would. Nothing on this planet can regrow cartilage that's already gone, so be careful with anything that claims it can. What UC-II does is calm the inflammation that's eating what's left. That slows the damage down and takes the pain with it.

No, it's not too late. Nothing on this planet can rebuild cartilage that's already gone, and we won't pretend it can. What UC-II does is calm the inflammation that causes the pain and keeps eating what's left. A lot of our customers were bone on bone with surgery already scheduled. It worked well enough that their doctors told them they could put the surgery off and keep doing what they're doing.

Everyone's different, but most people notice something around week 3 or 4. The knees are a little less stiff in the morning, or getting out of the car is easier. By week 8, most people notice a big difference and are back to the things they'd stopped doing, like the stairs, the garden or getting on the floor with the grandkids.

Yes, and a lot of our customers are in exactly that spot. The inflammation that wore out the first knee is still working on the other one. Protecting that knee is the best way to avoid a second surgery. The tendons and ligaments around the new knee also still need collagen, which is what the 9,000 mg of normal collagen is for.

UC-II has some research behind it for rheumatoid arthritis too. But this formula was designed around osteoarthritis, and we haven't tested it for RA. It might help, but there may be better options for RA, and we don't want to sell you something we aren't sure will work for you. Ask your rheumatologist first.

This one comes up a lot. HRT puts estrogen back, but for many women it never fully gets the knee inflammation under control, especially when it's been building for years. UC-II works on the immune system directly, so it doesn't depend on hormone levels. Many of our customers take both, and the two don't get in each other's way.

Yes. Menopause is the most common reason the body's anti-inflammatory gets switched off, but it isn't the only one. Age, old injuries and years of wear can do it too. UC-II works the same way no matter what switched it off.

Yes, that's exactly who it was made for. Before menopause, estrogen helped keep knee inflammation under control. After it drops, that job goes undone, and the inflammation starts eating the cartilage. UC-II tells the immune system to pick that job back up.

It works wherever the inflammation is, because UC-II works through the immune system, not on one joint. Knees usually go first because every stair puts about 4 times your body weight through them, so that's where most people notice it most. A lot of customers tell us their hands loosen up too, like opening jars or making a fist in the morning.

Yes. It's a food-based powder that goes in coffee or water, and it doesn't change how the shot works. Many of our customers take it alongside Ozempic, Wegovy or Mounjaro. If the shot makes your stomach sensitive, take your scoop with breakfast.

That's because it was normal collagen. Normal collagen is a building block. The body breaks it down and uses it for skin, hair and nails, because they're made of collagen. UC-II isn't used to build anything. It goes to the gut, where a process called oral tolerance tells the immune system to send its anti-inflammatory signal back to the joints. That's the job estrogen used to do.

Because what you're taking is almost certainly normal collagen. It's a building block for skin, hair and nails, so that's where it goes. It never had a way to calm the inflammation in the knees. More Than Collagen has 9,000 mg of normal collagen too, so you keep what you liked about your old one, plus 40 mg of UC-II for the knees. Most people simply swap it in.

Both, and each one has its own job. The 40 mg of UC-II is for the knees. It tells the immune system to calm the inflammation there. The 9,000 mg of normal collagen goes to the tendons and ligaments that hold the knee steady, and your skin, hair and nails get the leftovers.

It has the extras, and each one is there for a reason:

• MSM and astaxanthin are strong natural anti-inflammatories. They take the edge off in the first weeks while UC-II builds up.
• Hyaluronic acid thickens the fluid that cushions the joint.
• Vitamin C lets the body actually use the collagen.
• Vitamin D3, K2 and calcium keep the bone under the cartilage strong.

It's a food-based supplement, and food-based supplements like this generally don't interact with medication. If you take a blood thinner or any other prescription, check with your doctor first, just to be sure.

It has no turmeric or fish oil, the 2 supplements most often flagged with blood thinners. It does have 100 mcg of vitamin K2. That matters if you take warfarin, because vitamin K affects how warfarin works. Either way, show the label to your doctor before you start. Plenty of our customers on blood thinners take it with their doctor's OK.

Yes. You don't have to stop anything to start this. Keep your normal routine while UC-II builds up. Most people find they reach for the Advil less after a few weeks, without forcing it. If you get cortisone or gel shots, ask your doctor about timing, but there's no reason the two can't go together.

Yes, for almost everyone. There's no turmeric, which is what upsets most stomachs in joint supplements, and no fistful of giant pills. It's 1 scoop in your coffee. If your stomach is sensitive, take it with breakfast instead of on an empty stomach.

Most people don't notice anything except their knees. A small number feel a mild upset stomach in the first week while their body gets used to it, and taking it with food usually fixes that. If anything feels off, stop and talk to your doctor. You're still covered by the 60-day guarantee.

No. It's gluten free, has no dairy or soy ingredients, has 0 g sugar and is non-GMO. It's made in the USA.

It's not vegan, and we won't pretend otherwise, because collagen only comes from animals. Ours comes from beef, fish and chicken. The marine collagen is from fish, not shellfish, so it's fine if you avoid shellfish. There's 0 g sugar too.

Stir 1 scoop into your morning coffee, tea, water or a smoothie, hot or cold. It's unflavored and dissolves fully, so your coffee still tastes like coffee. There are no pills to swallow, which matters if your hands make pill bottles a fight.

Don't worry about it. Just take your scoop the next morning. 1 missed day won't undo anything. A week or more off usually will, because the signal needs to keep coming. Keeping the bag next to the coffee maker is the easiest way to never forget.

We'll be straight with you. UC-II works by sending a signal, and the body needs that signal every day. Most people who stop feel the stiffness creep back within 1 to 2 weeks. The good news is it settles down again once they start back up.

13 scoops, so about 2 weeks. Honestly, that isn't long enough to feel the full change, which is why we don't recommend starting with just 1.

Send it back within 60 days, even if the bag is empty, and get every penny back. That covers every order.

Most people pick 4 pouches, and here's why:

• UC-II takes a few weeks to start working, and the bigger changes usually show up around week 8.
• 1 pouch lasts about 2 weeks, so 4 pouches covers the full 8 weeks.
• It's also the lowest price per day.

And with the 60-day guarantee, you're covered the whole time.

Yes. It ships automatically, so you never run out. You get an email reminder a few days before every shipment, and you can skip, pause or cancel in 3 clicks, no phone call. Every order has the 60-day money-back guarantee, even if the bag is empty.

We'd rather keep you as a happy customer than trap you in a subscription and earn a bad review.

Log in, tap "Manage subscription" and tap "Cancel." That's 3 clicks. No phone call, no maze of "are you sure" screens. You also get an email 3 days before every shipment, so nothing ever ships by surprise. You can cancel or delay right from that email.

2 reasons:

• Amazon's fees would add about $15 to every bag, and we'd rather that money stay with you.
• Amazon is where most fake and under-dosed UC-II gets sold, often with less than the 40 mg from the studies.

Buying here is the only way to know you're getting the real thing.

Orders placed before 3pm ship the same day from the US. Shipping is free and insured, and tracking is emailed within 24 hours. Most orders arrive in 2 to 5 working days in the US, and 5 to 10 internationally.

Yes. We're a small company based in Draper, Utah. Every pouch is made in the USA, and every batch is tested by an outside lab before it ships. We're small enough that a real person answers every email, and we'd rather lose a sale than sell you something that won't help.